Advantages And Disadvantages Of Nifedipines

Advantages And Disadvantages Of Nifedipines

INTRODUCTION1–4

Nifedipine is calcium channel blocker widely used clinically, in the treatment of cardiovascular disorders, including hypertension and angina pectoris.1. It has poor aqueous solubility, resulting in variable dissolution rates and often–irregular bioavailability.2 The combination of low aqueous solubility and rapid absorption from the gastrointestinal tract leads to its classification into class II of the Biopharmaceutical Classification System3.

Pellets are agglomerates of fine powders or granules of bulk drugs and excipients single most important factor responsible for the proliferation of pelletized products is the popularity of controlled release technology in the delivery of drugs. When the pellets containing active ingredient are administered in–vivo in the form of suspensions, capsules, or disintegrating tablets, they offer significant therapeutic advantages over single unit dosage forms, since pellets ... Show more content on Helpwriting.net ...When formulated as modified release dosage forms, pellets are less susceptible to dose dumping than the reservoir–type single unit formulations.4 Micropellets technology delivers almost perfectly spherical particles exhibiting a very narrow particle size distribution and excellent flow properties and these are characterized by a smooth surface free of dust and thus provide optimal conditions for subsequent film coating. Controlled release pellets are manufactured either to deliver the bioactive agent at a specific site within the GIT or to sustain the action of drugs over an extended period of time. While these results have been traditionally achieved through the application of a functional coating material, at times the core pellets themselves have been modified to provide the desired effect. This further enhances the role of pellets in oral dosage form

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