Alzheimer's (ADEOA) Disease Analysis
The autosomal dominant early onset alzheimer's (ADEOA) disease is a mendelian genetic disease. ADEOA is a form of alzheimer's that affects patients earlier in life, specifically before the age of 65. Alzheimer's is a form of dementia that causes severe memory, cognitive, and behavior problems, and results in death normally 10 years after symptoms begin to affect the patient. It is caused by a mutation in one of the the amyloid precursor protein (APP), presenilin 1 (PSEN1), and or 2 (PSEN2) genes. One mutation is the amyloid precursor protein, located in 21q21.3, found in the lipocytes in the cerebrum which in diseased patients, produces beta amyloid by improperly dividing. The beta amyloid is found in the amyloid plaques which are present ... Show more content on Helpwriting.net ...Some major changes include the shriveling of the cortex, and shrinkage primarily in the hippocampus. The cortex damage results in limited cognitive and memory abilities, and the hippocampus shrinkage further destroys the patient's ability to create new
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